Bariatric Surgery and Pharmacokinetics of Amlodipine

• Status: Recruiting
• Trial end date: 2026-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study we investigate the pharmacokinetic effects of bariatric surgery on amlodipine.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Norwegian University of Science and Technology
• Collaborators: Alesund Hospital; Namsos Hospital; St. Olavs Hospital; Volvat Medisinsk Senter Stokkan
• Treatments: Amlodipine

Criteria

Inclusion Criteria:

• Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway

• Being a Norwegian citizen

Exclusion Criteria:

• Having previously undergone resections in the GI-tract