Based on Metabonomics Dryness Pathogen Type of OLP: a Dynamic Study
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Due to the change of life style, the incidence of oral cavity mucous membrane disease
increased.In this study，been done a large number of pre-clinical practice and some
experimental studies， based on the application of metabolomics technology to ultra-high
liquid-mass spectrometry metabolomics analyzer as the core means， The metabolism of pattern
recognition and combination of modern analytical techniques to measure blood and urine of
patients with OLP-specific clearance of endogenous metabolites，and after the intervention of
moss drink endogenous metabolites in the body as a whole group of. At the same time， the use
of flow cytometry,，ELISA， immunohistochemistry and other modern technology, research OLP
patients using clean moss drink before and after treatment of local lesions and peripheral
blood CD4 +，CD8 + lymphocytes，Th1 cytokines (IFN-γ， TNF-α)， Th2 cytokines (IL-4，10) the
dynamic changes. From metabolomics， cellular immunology， inflammation mechanism perspective
of local OLP lesions， peripheral blood and changes in endogenous metabolites in the
process,，in-depth study of traditional Chinese medicine to drink clean moss multi-component
multi-target treatment of this disease mechanism， is widely used in traditional Chinese
medicine treatment of OLP provide a theoretical basis for the promotion of Chinese medicine
Qingxian Yin in the oral mucosal disease in the application， effectively solve clinical
practice problems.