Baseline Cortical Haemodynamics in MS

• Status: Unknown status
• Trial end date: 2019-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will provide information on cortical haemodynamics in MS patients to address the discrepancies reported in previous literature, allowing further insight into the role of haemodynamics in the disease. It will also instruct us as to the most effective scanning protocols for future research. Developing a suitable protocol for studying perfusion longitudinally may also enable identification of new therapeutic interventions to normalise any perfusion abnormalities in MS patients.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Nottingham

Criteria

Inclusion Criteria (Healthy Volunteers):

• Male or female volunteers who are between the ages of 21 and 80.

• Able to give voluntary written informed consent to participate in the study.

• Able to understand the requirements of the study, including anonymous publication, and agree to co-operate with the study procedures.

Inclusion Criteria (Patients):

• Diagnosed with Multiple Sclerosis.

• Male or female volunteers who are between the ages of 21 and 80.

• Able to give voluntary written informed consent to participate in the study.

• Able to understand the requirements of the study, including anonymous publication, and agree to co-operate with the study procedures.

Exclusion Criteria:

• Any history of neurological illness other than MS.

• Known hypersensitivity to any MR or X-Ray contrast agent.

• Any history of renal failure or disease.

• Any history of allergies.

• Any history of circulation problems (vascular disease).

• Pregnancy or breastfeeding.

• MRI contraindications as screened on safety questionnaire (e.g. metal implants or pacemaker).

• Have taken part in any other clinical study within the previous 3 months.#

• Any contraindications provided from MRI or contrast agent safety forms.