Basiliximab for the Treatment of Acute Graft-versus-host Disease After Allogeneic Stem Cell Transplantation

• Status: Unknown status
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Graft-versus-host disease (GVHD) contributes substantially to transplant-related morbidity and mortality. Steroids remains first line therapy for acute GVHD but there is currently no consensus on second line therapy for those in whom steroids have been ineffective. Basiliximab has been shown to be a safe and effective immunosuppresant in the prevention and treatment of rejection after renal transplantation and its role in acute GVHD prophylaxis and treatment has been described favourably. This is a randomized control trial to investigate its efficacy and safety in the management of acute GVHD post allogeneic stem cell transplantation (SCT).

• Phase: N/A

Details

• Lead Sponsor: Hospital Authority, Hong Kong
• Collaborators: Novartis Pharmaceuticals; The Hong Kong Blood Cancer Foundation
• Treatments: Antibodies, Monoclonal; Basiliximab

Criteria

Inclusion Criteria:

• Grade II to IV acute GVHD after SCT

Exclusion Criteria:

• Known allergy to basilixmab