Bedtime Potassium Losartan on CKD With Nocturnal Hypertension Patients With Nondipping Blood Pressure Pattern

• Status: Not yet recruiting
• Trial end date: 2023-12-30
• Target enrollment: 0
• Participant gender: All

Summary

Nondipping blood pressure (BP) pattern is a potential independent risk factor for chronic kidney disease (CKD). Whether bedtime administration of potassium losartan has benefit for anti-hypertension and the prognosis of CKD patients is not clear. Patients with nondipping BP pattern or dipping BP pattern were enrolled in this study, and the patients with nondipping BP pattern were randomly divided into two groups and treated with bedtime or awakening doses of potassium losartan.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University
• Treatments: Losartan

Criteria

Inclusion Criteria:

• night BP is SBP≥120mmHg and/or DBP≥70mmHg；

• presence of CKD;

• estimated GFR (eGFR)<90 mL⁄ min ⁄ 1.73 m2 (using the Modification of Diet in Renal Disease Study equation) but >30 mL⁄ min ⁄1.73 m2;

• signed informed consent from participating patients.

Exclusion Criteria:

• pregnancy;

• tumor;

• infection;

• renal replacement;

• history of drug or alcohol abuse;

• night- or shift-work employment;

• treatment with steroids or hormonal therapy;

• acute changes in eGFR >30% in the past 3 months;

• presence of acquired immunodeficiency syndrome;

• CV disorders (unstable angina pectoris, heart failure, life-threatening arrhythmia, atrial fibrillation, kidney failure,and grade III or IV retinopathy);

• intolerance to ambulatory BP monitoring (ABPM);

• inability to communicate and comply with all of the study requirements.