Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)

• Status: Recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Craig Rush
• Collaborator: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Treatments: Duloxetine Hydrochloride; Ethanol; Methylphenidate

Criteria

Inclusion Criteria:

• able to speak/read English

• not seeking treatment at the time of the study

• one binge drinking episode (5+/4+ standard alcoholic drinks per drinking session for men and women, respectively) in the past 30 days

• recent alcohol use verified by ethyl glucuronide positive urine, as well as fulfillment of DSM-5 diagnostic criteria for alcohol use disorder

• ECG within normal limits

• otherwise healthy

• body mass index of 19-35

• females using an effective form of birth control and not pregnant or breast feeding

• judged by the medical staff to be psychiatrically and physically healthy

• able to abstain from alcohol for 12 hours prior to session

• no contraindications/allergies to duloxetine or methylphenidate