The specific aim of this project is to demonstrate that the decisional analysis/craving
regulation aspects of CBT reduce cocaine self-administration in subjects with cocaine use
disorder through diminished craving responses. Thirty non-treatment seeking human subjects
meeting diagnostic criteria for cocaine use disorder will complete an outpatient, crossover,
placebo-controlled study consisting of 1 practice and 9 experimental sessions. In each
experimental session, the reinforcing effects of intranasal cocaine will be determined under
one of three regulation of craving conditions that simulate CBT decisional analysis (i.e.,
negative instruction, positive instruction or a neutral "look" condition). After sampling the
dose of cocaine available in each session, subjects will complete the craving manipulation
assigned to that session, they will then rate their craving and finally they will have the
opportunity to earn the sampled dose in a progressive-ratio procedure. We hypothesize that
focusing on the negative effects of cocaine use will decrease craving and reduce cocaine
self-administration relative to the positive and "look" conditions, and that craving will be
positively correlated with self-administration outcomes.