Behavioral and Physiological Effects of Cocaine in Cocaine-dependent Participants Treated With Levodopa in Combination With Carbidopa and Entacapone (LCE)

• Status: Completed
• Trial end date: 2012-04-01

Summary

An inpatient safety study to characterize the cardiovascular and behavioral effects of cocaine administration in the presence of LCE. The proposed study involves an inpatient stay of 12 days during which participants will have two cocaine-administration sessions, each including five doses of smoked cocaine with ascending doses.

• Phase: Phase 1

Details

• Lead Sponsor: New York State Psychiatric Institute
• Collaborators: Columbia University; National Institute on Drug Abuse (NIDA)
• Treatments: Carbidopa; Cocaine; Entacapone; Levodopa