Bendamustine + Rituximab in Older Patients With Previously Untreated Diffuse Large B-cell Lymphoma
Status:
Completed
Trial end date:
2016-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to learn about the safety of the treatment with a
combination of bendamustine and rituximab and to find out what effects, both good and bad
this treatment has on DLBCL. In addition to learning about the combination of bendamustine
and rituximab, the researchers are interested in learning about how this cancer treatment
affects daily activities. Subjects will be asked to complete a Geriatric Assessment (GA). GAs
are designed to gather information on memory, nutritional status, mental health, and level of
social support. GAs are also designed to help the health care team understand how well
subjects can carry out their day to day activities and to briefly describe what other medical
conditions subjects may have. This assessment will help the health care team understand a
subject's "functional age" (the age a subject functions at) as compared to a subject's actual
age.
The researchers also want to learn how chemotherapy affects the aging process in our bodies.
This is done by measuring the amount of p16 in blood. Researchers want to understand if
chemotherapy changes the levels of p16 in blood.