Beta-Blocker Continuation Versus Interruption in Heart Failure Worsening

• Status: Completed
• Trial end date: 2009-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of the B-Convinced study is to demonstrate the non-inferiority of beta-blocker continuation compared to its interruption in patients with congestive heart failure who are treated by a beta-blocker and present with an episode of heart failure worsening with pulmonary oedema requiring hospital admission.

162 patients will be randomized in cardiology centers in France. Clinical status (primary endpoint) will be evaluated with a standardized questionnaire 3 days after hospital admission.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Adrenergic beta-Antagonists

Criteria

Inclusion Criteria:

• Patients with heart failure treated with beta-blocker; hospitalisation for heart failure worsening with pulmonary oedema.

• Left ventricular ejection fraction less than 40%

Exclusion Criteria:

• Indication of intravenous positive inotropic treatment

• Indication to withdraw beta-blocker treatment