Beta-Cell Function After Near-Normalisation of Blood Glucose

• Status: Completed
• Trial end date: 2007-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The incretin effect is attenuated in patients with type 2 diabetes mellitus partly due to impaired potentiation of beta-cell responsiveness to glucose by glucose dependent insulinotropic polypeptide and glucagon-like peptide-1 respectively. The aim of the present study was to investigate whether 4 weeks of near-normalization of blood glucose could improve the insulin responses to GIP and GLP-1 in patients with type 2 diabetes.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hvidovre University Hospital
• Treatments: Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1

Criteria

Inclusion Criteria:

• Age 18-70 years

• Type 2 diabetes diagnosed after 30 years of age

• BMI > 25

Exclusion Criteria:

• Severe complications to diabetes

• Abnormal liver and kidney function

• Haemoglobin below the lower limit

• Macroalbuminuria

• Systemic disease

• Pregnancy