Overview
Beta-blockade Effects on Memory for Cocaine Craving
Status:
Completed
Completed
Trial end date:
2011-07-01
2011-07-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The purpose of this study is to examine the effects of propranolol versus placebo on responses to cocaine cues in cocaine dependent individuals.Phase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Medical University of South CarolinaCollaborator:
National Institute on Drug Abuse (NIDA)Treatments:
Cocaine
Propranolol
Criteria
Inclusion Criteria:- Current cocaine dependence (within past month)
- Able to provide informed consent
- Use of birth control by female participants (barrier methods, surgical sterilization,
IUD, or abstinence)
- Live within 50-mile radius of research site
- Consent to remain abstinent from all drugs of abuse (except nicotine) for 24 hours
prior to inpatient admission and follow-up assessment
- Consent to random assignment to propranolol or placebo
Exclusion Criteria:
- Women who are pregnant, nursing or are of childbearing potential and not
practicing/using birth control
- Evidence or history of significant hematological, endocrine, cardiovascular,
pulmonary, renal, gastrointestinal or neurological disease
- Significant liver impairment
- History of or current psychotic disorder, current severe major depressive disorder,
bipolar affective disorder or a severe anxiety disorder
- Currently taking anti-arrhythmic agents, psychostimulants or other agents known to
interfere with heart rate and skin conductance monitoring
- Known or suspected hypersensitivity to propranolol
- Individuals taking medications that could adversely interact with the study
medication, including, but not limited to albuterol, insulin, or significant
inhibitors of CYP2D6
- Individuals with bronchial asthma or chronic obstructive pulmonary disease