Bevacizumab in Severe or Critical Patients With COVID-19 Pneumonia
Status:
Completed
Trial end date:
2020-05-02
Target enrollment:
Participant gender:
Summary
The novel identified coronavirus (SARS-CoV-2) in 2019 causes an nationwide outbreak as well
as public health crisis in China, and expands globally. Pulmonary edema is one of the most
detrimental symptoms and usually presents in severe and critical coronavirus disease
(COVID-19), resulting in dyspnea, acute lung injury (ALI) ,acute respiratory distress
syndrome (ARDS), and even death. Recent evidence revealed higher levels of blood Vascular
Endothelial Growth Factor (VEGF) in COVID-19 patients compared with healthy controls. VEGF is
considered as the most potent vascular permeability inducers. Numerous studies have revealed
that VEGF was a key factor and a potential therapeutic target in ALI and ARDS. Bevacizumab,
an anti-VEGF drug, approved by the FDA on February 26, 2004 and widely used in clinical
oncotherapy, is a promising drug for ALI/ARDS in COVID-19 through suppression of pulmonary
edema.
Phase:
Phase 2
Details
Lead Sponsor:
Qilu Hospital of Shandong University
Collaborators:
Moriggia-Pelascini Gravedona Hospital Renmin Hospital of Wuhan University