Overview

Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure

Status:
Unknown status
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
To investigate the effect of hydralazine isosorbide dinitrate on clinical outcomes, symptoms, cardiac parameters and functional status of African patients hospitalized with AHF and left ventricular dysfunction during 24 weeks of therapy. Administration of hydralazine/nitrates will be superior to placebo administration in reducing HF readmission or death, improving dyspnoea, reducing blood pressure and brain natriuretic peptide (BNP) in African patients admitted with AHF and left ventricular dysfunction.
Phase:
Phase 3
Details
Lead Sponsor:
University of Cape Town
Collaborator:
Momentum Research, Inc.
Treatments:
Hydralazine
Isosorbide
Isosorbide Dinitrate
Isosorbide-5-mononitrate