Bicarbonate Administration in Kidney Transplant Recipients
Status:
Completed
Trial end date:
2020-03-25
Target enrollment:
Participant gender:
Summary
Metabolic acidosis is associated with vascular endothelial dysfunction and is a common
complication in patients who have received a kidney transplant. Kidney transplant recipients
(KTR) with lower serum bicarbonate levels, even within the normal range, have an increased
risk of graft loss and mortality. The investigators propose a prospective, double-blind,
randomized, placebo-controlled, 18-week crossover pilot study to examine the effects of
sodium bicarbonate on vascular endothelial function, graft function, and cognitive function
in 20 KTR patients.