Bicarbonated Ringer's Solution Versus Lactated Ringer's Solution in Patients With Septic Shock

• Status: Not yet recruiting
• Trial end date: 2021-05-30
• Target enrollment: 0
• Participant gender: All

Summary

In this prospective randomized controlled trial, investigators aim to study the effects and safety of bicarbonated Ringer's solution in patients with septic shock compared with lactated ringer's solution, and provide evidence for current fluid resuscitation strategies for septic shock.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhongnan Hospital
• Treatments: Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• 1. At the age of 18 to 75;

• 2. Being treated in the ICU;

• 3. Diagnosed as septic shock according tho the definition of Sepsis 3.0 with fluid resuscitation requirement.

Exclusion Criteria:

• 1. Severe hepatic failure;

• 2. Possible brain injury;

• 3. With absolute contraindications for central vena catheterization;

• 4. Ever participated in another clinical trial within 30 days prior enrollment;

• 5. Have corrected metabolic acidosis through alkaline drug application within 24 hours prior to enrollment;

• 6. Hypermagnesemia or hypothyroidism;

• 7. Pregnant of breast-feeding women;

• 8. Considered inevitable death;

• 9. Other situations where investigators think enrollment is not appropriate.