Bileacid Malabsorption and GLP-1 Secretion

• Status: Completed
• Trial end date: 2017-08-04
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to examine the influence of BAM on postprandial GLP--1 secretion and glucose homeostasis, both with and without bile acid sequestration.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Gentofte, Copenhagen
• Treatments: Colesevelam Hydrochloride

Criteria

Inclusion Criteria:

• Northern European origin

• Normal haemoglobin

• Age above 18 years and below 70 years

• Informed and written consent

• BMI > 23 kg/m2 and < 35 kg/m2

• Normal fasting plasma glucose (FPG) < 6.5 mM) and glycated haemoglobin (HbA1c) < 48 mmol/mol

Exclusion Criteria:

• Liver disease (alanine aminotransferase (ALAT) and/or serum aspartate aminotransferase (ASAT) >2 times normal values) or history of hepatobiliary disorder

• Gastrointestinal disease (except BAM), previous intestinal resection, cholecystectomy or any major intra-abdominal surgery

• First-degree relatives with diabetes

• Nephropathy (serum creatinine >150 µM and/or albuminuria

• Treatment with medicine that cannot be paused for 12 hours

• Hypothyroidism or hyperthyroidism

• Treatment with oral anticoagulants

• Active or recent malignant disease

• Any treatment or condition requiring acute or sub-acute medical or surgical intervention

• Lack of effective birth control in premenopausal women

• Any condition considered incompatible with participation by the investigators