Overview

Biliary Atresia, Hepatic Buffer Response and Sevoflurane

Status:
Completed

Trial end date:
2014-02-01

Target enrollment:
0

Participant gender:
All

Summary

To evaluate the effects of sevoflurane on hepatic blood flow (HBF) and hepatic arterial buffer response (HABR) in infants with obstructive jaundice by Doppler ultrasound.Twenty-five infants with biliary atresia (1-3 months-of-age) scheduled for a Kasai procedure were enrolled. portal vein blood flow (PBF), hepatic arterial blood flow (HABF) and hepatic blood flow (HBF) were measured by Doppler ultrasound before induction, and after inhalation of 2 and 3% sevoflurane.

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Children's Hospital of Fudan University

Treatments:

Sevoflurane

Criteria

Inclusion Criteria:

- persistent yellow skin or sclera, pale stool (in severe cases, clay-like), and
hepatomegaly;

- increased serum bilirubin (progressively or no decline after increase), increased
total bilirubin (TBil) dominated by increased direct bilirubin (DBil) (>60%);

- elevated liver enzymes;

- ultrasound confirmation of poor gallbladder filling and signs of liver fibrosis;

- with radionuclide imaging confirmation of obstructed biliary excretion

Exclusion Criteria:

- concomitant cardiovascular or abdominal organ malformations