Bioavailability, Pharmacokinetics and Tissue Distribution of R-flurbiprofen Capsules in Healthy Subjects
Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
For previous clinical trials, R-flurbiprofen has been prepared in tablet form. In this study
R-flurbiprofen, will be available as gelatine capsules.
This study aims to show the bioavailability of R-flurbiprofen when administered in gelatine
capsules. The serum availability will be determined by analysis of pharmakokinetic (pK)-blood
samples at different time points. To assess the safety of the administered capsules adverse
events will be documented.
Analysis of lipid signaling molecules in plasma will be done to assess the role of this
molecules as variable for therapeutic effects.
Phase:
Phase 1
Details
Lead Sponsor:
Gerd Geisslinger
Collaborator:
Fraunhofer Institute for Molecular Biology and Applied Ecology