This is a bioimaging study of 89Zr-M7824 PET scans in patients with advanced or metastatic
non-small cell lung cancer who will be receiving M7824 alone or with standard of care
chemotherapy. M7824 is a bifunctional fusion protein that combines an anti-PD-L1 antibody and
the extracellular domain of TGFβ receptor II (TGFβRII) as a TGFβ neutralizing 'trap', into a
single molecule.