Biological Effects of Citrate-buffered Solutions on Dialysis Efficiency and Systemic Inflammation

• Status: Completed
• Trial end date: 2015-07-30
• Target enrollment: 0
• Participant gender: All

Summary

In this study 45 patients undergoing weekly dialysis for chronic end stage renal disease will be enrolled. The patients will be treated with a standard dialysis solution, containing acetate buffer, for 3 months; subsequently the acetate will be substituted with citrate anion for the 3 following months and then, the last 3 months, the standard acetate-solution will be restarted. The aim of the study is to assess if acetate-to-citrate switch in the dialysis solution influences dialysis efficiency and patient inflammatory state.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Azienda Ospedaliera Città della Salute e della Scienza di Torino
• Treatments: Citric Acid; Dialysis Solutions; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• age >18 years

• creatinine clearance <5ml/min

• treatment with bicarbonate HD (BIC-HD) or on-line hemodiafiltration (OL-HDF) 3 times per week for at least 6 months prior to study start

• treated at Dialysis unit of: Città della Salute e della Scienza University Hospital, Torino, Italy

Exclusion Criteria:

• known neoplastic disease

• active chronic inflammatory disease

• active acute inflammatory disease