Biological Markers of Response to Treatment in Major Depressive Disorder

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to find out if two tests are useful in predicting whether someone with depression will get better when he or she is treated with an FDA approved antidepressant medication (either citalopram or escitalopram).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Treatments: Citalopram; Dexetimide; Serotonin; Serotonin Uptake Inhibitors

Criteria

Inclusion Criteria:

• Ages 18-65

• Meet criteria for current Major Depressive Disorder

• Antidepressant medication-free for at least 2 weeks prior to the start of the study

Exclusion Criteria:

• Pregnant or breastfeeding women

• Anyone who is suicidal

• Anyone with an unstable medical condition (cardiovascular, hepatic, renal, respiratory, endocrine, neurological, or hematological), substance abuse problem within the past 6 months, psychoses (past or current), hypothyroidism, or hypomania

• Anyone currently taking an SSRI

• Past intolerance to Lexapro or Celexa