Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy

• Status: Completed
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Overall aim of this work is to evaluate new methods of resuscitation that can be applied by front-line responders on the battlefield, in civilian life, or which can be used during initial resuscitation in the first fixed facility to which the injured patient is brought.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Missouri, Kansas City
• Collaborator: United States Department of Defense

Criteria

Inclusion Criteria:

• Blunt or penetrating trauma patients who meet Truman Medical Center criteria for a trauma activation.

• These patients will typically be in shock and have blunt injuries or penetrating trauma.

• Patients must be alert, awake, oriented, and responsive and be English speaking males or females between the ages 21-65.

Exclusion Criteria:

• traumatic cardiac arrest patients,

• pregnant patients,

• interhospital transfer patients,

• non-English speaking patients,

• patients with suspected or confirmed Human Immunodeficiency Virus (HIV) or AIDs based on clear history,

• prior laboratory tests, or strong clinical suspicion; patients with clinical evidence of impaired mental function;

• patients with continuing hypotension or tachycardia after resuscitation;

• patients with blood alcohol in excess of 80mg/dl;

• signs suggestive of coagulopathy;

• allergy to glutamine;

• liver disease or renal disease.