Biomarkers of Antidepressant Treatment in Adolescents With Major Depression (The Adolescents MDD Study)
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This study will aim to evaluate the use of Electroencephalography (EEG) biomarkers in
adolescent depression. Two specific hypotheses will be tested:
H1: Early decreases in prefrontal cordance values will be greater in responders to
antidepressant therapy than in medication non-responders.
H2: Subjects with high Antidepressant Treatment Response(ATR) Index values [i.e., predicted
to show symptomatic improvement with fluoxetine (FLX)] will achieve greater improvement in
symptoms and in functional status than those with low ATR values.
Exploratory analyses will be undertaken to compare and contrast the cordance changes and ATR
values in medication and placebo-treated responders and non-responders.