Bisphosphonates Effects On Alveolar Bone Among Osteoporotic Women

• Status: Completed
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

Osteoporosis is a public health problem. It is a skeletal disease being treated by Bisphosphonates as the first choice medication. The effects of these drugs were investigated for periodontal disease treatment both locally and systemically. However, it is very important to know their indirect effects on alveolar bone (i.e. their effects when used for treating osteoporosis). So, in this study, alternations that involve the alveolar bone when osteoporotic women use bisphosphonates will be studied radiologically using cone-beam CT and digital panoramic radiography. The goal is to provide dentists with information about changes in the characterization of the alveolar bone among these women. This is important for both periodontology and implantology. Maxillary and mandibular bone structural characterization among osteoporotic women had not been studied before. Furthermore, in an opposite direction, dental radiographs may aid in detecting osteoporosis.

Osteoporotic women, under bisphosphonates therapy or not, will be invited to participate in this study. In addition, osteopenic and normal women regarding bone fragility will be included too, for comparison purposes. Panoramic radiographs will be taken. In addition, women under bisphosphonates for 6 months or more will be scanned by Cone -beam CT as it can give an idea about bone histomorphometry with a low radiation dose.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Damascus University
• Treatments: Diphosphonates

Criteria

Inclusion Criteria:

• Women with osteoporosis who already use bisphosphonates.

• Women with osteoporosis who are not under bisphosphonates yet, or are not indicated for such therapy.

• Women with osteopenia either using or not bisphosphonates.

Exclusion Criteria:

• Women with bone diseases other than osteoporosis or osteopenia