Bleach Bath Treatment of Adults With Atopic Dermatitis

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This is pilot, mechanistic study to address whether bleach baths given to adult subjects with atopic dermatitis or eczema, who are colonized with the bacteria Staphylococcus aureus, will significantly alter their skin microbiome and in so doing improve their skin barrier, diminish expression of inflammatory proteins in the skin and improve itch. To answer these questions the investigators will perform a 3-month, pilot, investigator-initiated, single-center, open-label clinical study. This study will allow us to test the following hypothesis: 1) that bleach baths will normalize skin barrier function, 2) that bleach baths will diminish the local inflammatory response in the skin, and 3) that bleach baths will improve validated measures of itch (also called pruritus).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Rochester
• Collaborators: National Eczema Association; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Treatments: Eusol; Sodium Hypochlorite

Criteria

Inclusion Criteria:

• Moderate to severe Atopic dermatitis: Eczema Area and Severity Index (EASI) score ≥ 10.

• Skin culture positive for Staphylococcus aureus

• Must have active skin disease on the day of enrollment.

Exclusion Criteria:

• Unwillingness or inability to complete informed consent

• Lidocaine or Novocain allergy

• History of keloid formation

• Course of systemic antibiotics or antivirals within 2 weeks prior to enrollment.