Blend to Limit Oxygen in ECMO: A Randomised Controlled Registry Trial

• Status: Recruiting
• Trial end date: 2023-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To determine in patients requiring venoarterial (V-A) ECMO, whether the use of a conservative as compared with liberal oxygen strategy, results in a greater number of ICU-free days at day 60.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Australian and New Zealand Intensive Care Research Centre

Criteria

Inclusion Criteria:

• Patients ≥18 years who are commenced on V-A ECMO for severe cardiac and/or respiratory failure or following refractory cardiac arrest.

Exclusion Criteria:

• Greater than 6 hours have elapsed from the time of initiation of ECMO to randomisation

• Patients who are suspected or confirmed to be pregnant

• Where an indication exists for a specific oxygen target as part of clinical care (e.g. carbon monoxide poisoning)

• Patients who are already enrolled in another oxygen titration study

• Patients not willing to receive blood products (e.g. Jehovah's Witness)

• Where the treating physician deems the study is not in the patient's best interest