Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.

• Status: Completed
• Trial end date: 2020-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Introduction: Septic shock leads to high morbidity and mortality in critically ill patients. Several lower-case scientific studies have supported the synergistic positive effect of vitamin C, thiamine, and hydrocortisone on sepsis-induced organ dysfunction.

Aim: Our aim was to investigate the effect of vitamin complex on organ failure, laboratory parameters, respiratory and antibiotic treatment, intensive care time, and mortality in septic shock patients.

Material and methods: In our retrospective and prospective analysis, we collected parameters from 43 (23 vitamin-treated, 20 control) septic shock patients. Patients treated with vitamin, they received vitamin C (4x1500 mg), thiamine (2x200 mg) for three days (2). In other respects, and for hydrocortisone (200 mg / 24h), both groups of patients received treatment according to the European Sepsis Recommendation. SPSS (V-21) data were used for data collection, Kolmogorov-Smirnov, Wilcoxon, Mann-Whitney U tests were used for statistical analysis.

Ethical license: 7849-PTE 2019.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Pecs
• Treatments: Thiamine

Criteria

Inclusion Criteria:

• septic shock

• intensive care unit administration

Exclusion Criteria:

• under age 18

• above age 80

• moribund patients

• pregnant patients

• active kidney stone

• inability to obtain consent

• viral or mixed sepsis

• missed dose of vitamin C/ thiamin or hydrocortisone

• Physician refused

• Vitamin C / Thiamine/ Hydrocortisone for other indications