Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.
Status:
Completed
Trial end date:
2020-03-01
Target enrollment:
Participant gender:
Summary
Introduction: Septic shock leads to high morbidity and mortality in critically ill patients.
Several lower-case scientific studies have supported the synergistic positive effect of
vitamin C, thiamine, and hydrocortisone on sepsis-induced organ dysfunction.
Aim: Our aim was to investigate the effect of vitamin complex on organ failure, laboratory
parameters, respiratory and antibiotic treatment, intensive care time, and mortality in
septic shock patients.
Material and methods: In our retrospective and prospective analysis, we collected parameters
from 43 (23 vitamin-treated, 20 control) septic shock patients. Patients treated with
vitamin, they received vitamin C (4x1500 mg), thiamine (2x200 mg) for three days (2). In
other respects, and for hydrocortisone (200 mg / 24h), both groups of patients received
treatment according to the European Sepsis Recommendation. SPSS (V-21) data were used for
data collection, Kolmogorov-Smirnov, Wilcoxon, Mann-Whitney U tests were used for statistical
analysis.
Ethical license: 7849-PTE 2019.