Blood Flow and Vascular Function in Cystic Fibrosis

• Status: Completed
• Trial end date: 2018-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections. However, the physiological mechanisms for this reduced exercise capacity are unknown. The investigators laboratory recently published the first evidence of systemic vascular dysfunction in patients with CF. Therefore, it is reasonable to suspect that the blood vessels are involved with exercise intolerance in CF. This study will look at how 1) blood flow and 2) artery function contribute to exercise capacity in CF.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Augusta University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Polystyrene sulfonic acid; Sildenafil Citrate

Criteria

Inclusion Criteria.

• Diagnosis of CF and healthy controls

• Men and women (greater than 18 yrs. old)

• Resting oxygen saturation (room air) greater than 90%

• Forced expiratory volume (FEV1) percent predicted greater than 30%

• Patients with or without CF related diabetes

• Traditional CF-treatment medications

• Ability to perform reliable/reproducible pulmonary function tests (PFT)

• Clinically stable for 2 weeks (no exacerbations or need for antibiotic treatment within 2 weeks of testing or major change in medical status)

Exclusion Criteria.

• Children less than 17 years old

• Body mass less than 20 kg

• A diagnosis of pulmonary arterial hypertension (PAH)

• FEV1 less than 30% of predicted

• Resting oxygen saturation (SpO2) less than 90%

• Self-reported to be a smoker

• Current use of any vaso-active medications

• History of migraine headaches

• Pregnant or nursing at the time of the investigation

• A clinical diagnosis of cardiovascular disease, hypertension, or CF related diabetes