Blood Levels of Local Anaesthetic in Knee Arthroplasty Using a Continuous Infusion Device

• Status: Unknown status
• Trial end date: 2014-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary goal is to evaluate ropivacaine blood concentrations during and after local anaesthetic (ropivacaine) infiltration - the Caledonian technique - for total knee replacement surgery. The investigators plan to measure these levels by testing blood samples taken over a timed period.

This will allow us to confirm whether the current regimen of local anaesthetic use is within safe limits.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Golden Jubilee National Hospital
• Collaborators: B. Braun Medical Inc.; University of Strathclyde
• Treatments: Anesthetics; Anesthetics, Local; Ropivacaine

Criteria

Inclusion Criteria:

• Male or female patients greater than 65 years of age

Exclusion Criteria:

• Patients with a known sensitivity/allergy to ropivacaine or amide-type local anaesthetics

• Patients who are not suitable for the Caledonian technique

• Patients who refuse or are unable to give consent

• Patients undergoing bilateral hip replacements

• Patients with known heart, liver or kidney failure