Blood Pressure After Endovascular Stroke Therapy-II

• Status: Recruiting
• Trial end date: 2023-03-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the safety of lowering blood pressure in acute stroke patients that are successfully treated with a mechanical thrombectomy procedure. The investogators will evaluate the hypothesis that lower blood pressure management strategies do not result in larger volume of stroke or worse 3-month clinical outcome in these patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Cincinnati; Vanderbilt University Medical Center
• Collaborators: National Institute of Neurological Disorders and Stroke (NINDS); Vanderbilt University Medical Center
• Treatments: Hydralazine; Labetalol; Nicardipine

Criteria

Inclusion Criteria:

• Adult patients (≥18 years)

• Undergoing successful EVT (defined as modified Thrombolysis in Cerebral Ischemia Score, mTICI, ≥2b) for an occlusion in the anterior cerebral circulation large vessel (internal carotid artery and M1 or M2 segments of the middle cerebral artery).

• Intervention will be initiated only for those with a successful recanalization (modified Thrombolysis in Cerebral Ischemia Score ≥ 2b).

• Undergoing a baseline CT or MR perfusion study

• Those with unsuccessful recanalization (mTICI 0-2a) will be not intervened upon.

Exclusion Criteria:

• Known heart failure with ejection fraction <30%

• Presence of a left ventricular assist device

• Patients undergoing extracorporeal membrane oxygenation

• Pregnancy

• Enrollment in any other clinical trial