Blood Pressure Interaction Between Sildenafil and Sublingual Glyceryl Trinitrate (GTN) in Men With Angina

• Status: Completed
• Trial end date: 2005-09-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of the study is to determine for how long sildenafil potentiates the blood pressure reduction that occurs with glyceryl trinitrate in men with angina.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Edinburgh
• Collaborator: Pfizer
• Treatments: Citric Acid; Nitroglycerin; Sildenafil Citrate

Criteria

Inclusion Criteria:

• Male

• Stable angina with one of:

• Classical history of exertional angina pectoris

• Previous diagnostic exercise test

• Angiographic evidence of CAD

• Aged 30 to 80 years

• Weight between 60 and 100 Kg

Exclusion Criteria:

• Regular treatment with long-acting nitrates or nicorandil where these cannot be withdrawn 72 hours prior to the study

• Myocardial infarction, unstable angina, stroke or transient cerebral ischaemia within 3 months

• Systolic BP > 170 mmHg or diastolic BP > 100 mmHg

• Systolic BP < 100 mmHg or diastolic BP < 60 mmHg

• Orthostatic hypotension (> 20 mmHg fall in systolic BP on standing)

• Diabetes treated with oral hypoglycaemic agents or insulin

• Any clinically significant disease other than stable angina, excepting other cardiovascular disease risk factors, e.g. smoking, hypercholesterolaemia and diet-controlled diabetes

• Taking any drug that interacts with sildenafil

• Evidence of drug abuse