Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myeloid Leukemia
Status:
Completed
Trial end date:
2001-09-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die. Peripheral stem cell or bone marrow transplantation may be able
to replace immune cells that were destroyed by chemotherapy used to kill tumor cells.
Sometimes the transplanted cells can make an immune response against the body's normal
tissues. Stem cells that have been treated in the laboratory with filgrastim may prevent this
from happening. Combining chemotherapy with bone marrow or peripheral stem cell
transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more
cancer cells. It is not yet known which treatment is more effective for chronic myeloid
leukemia.
PURPOSE: Randomized phase III trial to compare the effectiveness of donor peripheral stem
cell transplantation with donor bone marrow transplantation in treating patients with chronic
myeloid leukemia.