A registry trial evaluating resection of the primary breast tumor in women presenting with de
novo stage IV breast cancer with bone metastasis only. Previous reports of carefully selected
patients presenting with stage IV breast cancer suggest that surgery on the primary tumor may
result in improved survival, but this remains unproven. The early results of our ongoing
trial MF07-01 trial (a phase III randomized controlled trial of breast cancer women with
distant metastases at presentation who receive loco-regional treatment for intact primary
tumor compared with those who do not receive such treatment) showed that patients with bone
metastasis only have a trend toward improved survival with initial surgery.