Bone Resorption, Osteoclastogenesis and Adalimumab
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
Osteoclastic bone resorption depends on both the capacity to generate osteoclasts
(osteoclastogenesis) and on individual osteoclast activity. The investigators objective is to
study the effect of anti-TNF therapy on the number of osteoclast precursors in the peripheral
blood of patients with Rheumatoid Arthritis, on in vitro osteoclastogenesis and on osteoclast
activity before and during the treatment of patients with Rheumatoid Arthritis with
Adalimumab.