Boosting REcanalization of Thrombectomy for Ischemic Stroke by Intra-arterial TNK (BRETIS-TNK)
Status:
Recruiting
Trial end date:
2021-09-30
Target enrollment:
Participant gender:
Summary
Thrombolysis and endovascular thrombectomy are the most efficient treatments for acute
ischemic stroke patients in time window. However, sufficient recanalization (mTICI2b-3) can
't be acquired in all patients under thrombectomy. The EXTEND-IA TNK study indicated that
tenecteplase before thrombectomy was associated with a higher incidence of reperfusion and
better functional outcome than alteplase among patients with ischemic stroke treated within
4.5 hours after symptom onset. This study intends to explore whether a combination of
thrombectomy and intra-arterial TNK administration can increase recanalization rate after the
first attempt of thrombectomy device pass for ischemic Stroke.