Overview
Bortezomib in Treating Patients With Mantle Cell Lymphoma
Status:
Completed
Completed
Trial end date:
2009-12-21
2009-12-21
Target enrollment:
0
0
Participant gender:
All
All
Summary
RATIONALE: Bortezomib may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. PURPOSE: Phase II trial to study the effectiveness of bortezomib in treating patients who have previously untreated or relapsed mantle cell lymphoma.Phase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
NCIC Clinical Trials GroupTreatments:
Bortezomib
Criteria
DISEASE CHARACTERISTICS:- Histologically or cytologically confirmed relapsed or untreated mantle cell lymphoma
- No refractory disease defined as progression while on chemotherapy or within 1
month after completion of chemotherapy
- At least 1 bidimensionally measurable disease site*
- Lymph nodes at least 1.5 cm by 1.5 cm by spiral CT scan OR
- Non-nodal lesions (e.g., skin lesion or nodules) at least 1 cm by 1 cm by MRI, CT
scan, or physical exam NOTE: *Bone lesions are not considered bidimensionally
measurable disease
- No pre-existing ascites or pleural effusion
- No known CNS involvement by lymphoma
PATIENT CHARACTERISTICS:
Age:
- 18 and over
Performance status:
- ECOG 0-2
Life expectancy:
- At least 12 weeks
Hematopoietic:
- Absolute granulocyte count at least 1,500/mm^3
- Platelet count at least 75,000/mm^3
Hepatic:
- Bilirubin no greater than 1.5 times upper limit of normal (ULN)
- AST or ALT no greater than 2.5 times ULN
Renal:
- Creatinine no greater than 1.5 times ULN
Cardiovascular
- LVEF at least 45% by echocardiogram or MUGA
Pulmonary
- No pre-existing shortness of breath greater than grade 1
Other:
- No uncontrolled bacterial, fungal, or viral infections
- No pre-existing edema greater than grade 1
- No pre-existing neuropathy greater than grade 1
- No other malignancy within the past 5 years except adequately treated nonmelanoma skin
cancer or carcinoma in situ of the cervix
- No other serious illness or medical condition that would preclude study compliance
- No geographical conditions that would preclude study compliance
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- See Chemotherapy
- Prior rituximab allowed
- No prior radioactive monoclonal antibody therapy
Chemotherapy:
- See Disease Characteristics
- No prior high-dose chemotherapy with stem cell transplantation
- No more than 2 prior systemic chemotherapy regimens
- Same chemotherapy combination given for first-line and second-line therapy is
considered 2 regimens
- No prior flavopiridol
- At least 6 weeks since prior chemotherapy
- No concurrent cytotoxic chemotherapy
Endocrine therapy:
- No concurrent corticosteroids
Radiotherapy:
- No prior radiotherapy to 25% or more of functioning bone marrow
- At least 4 weeks since prior radiotherapy (except low-dose nonmyelosuppressive
radiotherapy) and recovered
- No concurrent radiotherapy to the sole site of measurable disease
Surgery:
- At least 2 weeks since prior major surgery
Other:
- No prior investigational therapy
- No other concurrent anticancer therapy
- No other concurrent investigational anticancer therapy