Botulinum Toxin Effects on Plantar Ulcer Recurrence
Status:
Completed
Trial end date:
2010-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this grant is to collect pilot data to assess the amount of botulinum toxin
that needs to be injected into the calf muscles of subjects with diabetes mellitus,
peripheral neuropathy, and a plantar ulcer to decrease muscle strength. We hypothesize that a
decrease in plantar flexor muscle strength will temporarily decrease plantar pressure. The
decrease in plantar pressure will provide temporary protection to the new tissue as it gains
tolerance to high stress with the long term potential outcome as a decrease in the ulcer
recurrence rate.
Phase:
N/A
Details
Lead Sponsor:
Washington University School of Medicine
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)