Botulinum Toxin Injection for Functional Popliteal Artery Entrapment Syndrome
Status:
Withdrawn
Trial end date:
2019-12-31
Target enrollment:
Participant gender:
Summary
Failure to adequately diagnose and treat patients with functional popliteal artery entrapment
syndrome (PAES) leads to continued pain, loss of function and poor quality of life for many
patients nationwide. Currently, the primary treatment for functional PAES involves muscle
resection, sometimes involving large segments of muscle, which itself can lead to functional
impairment. As such, a less invasive treatment for functional PAES is desirable. The focus of
this work is to determine whether Botulinum toxin type A (BTX-A) injections into the
gastrocnemius muscle can lessen the mechanical forces placed on the popliteal artery by the
involved muscle, thereby improving symptoms caused by impaired distal blood flow.
Phase:
Phase 2
Details
Lead Sponsor:
Stanford University
Treatments:
abobotulinumtoxinA Botulinum Toxins Botulinum Toxins, Type A onabotulinumtoxinA