Botulinum Toxin Injection in Neck Muscles in Cervicogenic Headache

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the effect and side-effects of injections with botulinum toxin in neck muscles in cervicogenic headache compared to injections with sodium water.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Norwegian University of Science and Technology
• Treatments: Botulinum Toxins

Criteria

Inclusion Criteria:

• Headache strictly unilateral without side-shift

• Traits indicating involvement of neck structures, fulfilling at least 2 of the following:

I. Reduced neck range of motion II. Typical headache can be elicited by palpation or pressure on muscles of the occiput or in the neck.

III. Typical headache can be precipitated by certain neck movements or by adopting a certain position of the head.

IV. There is a radiation of pain to the ipsilateral shoulder or arm.

• Positive effect of blockades. (In this study only a blockade of the greater occipital nerve will be applied).

• The condition has lasted for more than 1 year.

• The headache should be present more than 15 days a month, and the frequency should be based on a headache diary filled in the last month before inclusion.

Exclusion Criteria:

• Cervical spinal stenosis, cervical disc herniation, or other neck pathology that should be treated surgically.

• Malignant disorder.

• Rheumatic disorder or other disorders which induces analgesic use.

• other clinically relevant disease (liver, kidney, endocrinological, metabolical, systemic, psychiatric).

• Frequent other headache type that cannot be distinguished from cervicogenic headache.

• Pending or ongoing litigation for head- or neck trauma.