Botulinum Toxin Injection to Prevent Ventricular Arrhythmias

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this prospective non-randomized study was to assess the efficacy and safety of endomyocardial botulinum toxin injection in left ventricle for preventing ventricular arrhythmias.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Meshalkin Research Institute of Pathology of Circulation
• Treatments: Botulinum Toxins

Criteria

Inclusion Criteria:

• symptomatic ventricular arrhythmias

• drug-resistance

• unsuccessful one or more ablation procedure with future unreasonable tries

Exclusion Criteria:

• Previous heart surgery and AF ablation procedure

• Emergency CABG

• Unstable angina or heart failure

• Use antiarrhythmic drugs within 5 elimination half-lives of the drug (or within 2 months for amiodarone)

• Requiring concomitant valve surgery

• Left ventricle ejection fraction <35%

• Unwillingness to participate