Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb Joint
Status:
Terminated
Trial end date:
2015-10-01
Target enrollment:
Participant gender:
Summary
Basal arthritis of the thumb is a common condition with increased prevalence in
post-menopausal women, obese persons, and the elderly. Surgical options are varied and
efficacious, but not all patients are candidates for surgery. The successes and pitfalls of
previous, similar trials are carefully considered in the creation of our own. Though steroid
injection is the standard of care in basal joint arthritis, current data does not support its
efficacy beyond placebo effect. No trial has yet examined the efficacy of botulinum toxin
type A (BTX-A) injection into the basal thumb joint nor compared it to steroid. Since
efficacy of steroid is questionable at best, our hope is that BTX-A injection of the basal
joint might be the next great tool in treating this common, debilitating disease.
Phase:
Phase 4
Details
Lead Sponsor:
University of Missouri-Columbia
Treatments:
abobotulinumtoxinA Botulinum Toxins Botulinum Toxins, Type A incobotulinumtoxinA Lidocaine onabotulinumtoxinA Triamcinolone Triamcinolone Acetonide Triamcinolone diacetate Triamcinolone hexacetonide