Botulium Toxin Type A In Non Infectious Chronic Rhinosinusitis

• Status: Completed
• Trial end date: 2021-07-15
• Target enrollment: 0
• Participant gender: All

Summary

The present work aims to assess the effectiveness and safety of topical application of BTX - A compared with its intra turbinate injection in controlling the symptoms in non infectious chronic rhinosinusitis patients

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Benha University
• Treatments: abobotulinumtoxinA; Botulinum Toxins, Type A

Criteria

Inclusion Criteria:

• Patients with persistent symptoms of chronic non infectious rhinosinusitis not responding to previous lines of treatment including antihistaminics ,nasal decongestant, and or nasal steroid spray will be included in this study.

Exclusion Criteria:

• Patients with major structural deformities(septal deviation , adenoid hypertrophy, nasal valve pathology or nasal polyps).

• Having systemic illness such as DM, HTN, Malignancy or Tuberculosis.

• History of nasal surgery such as turbinate reduction surgery orseptoplasty.

• Acute rhinosinusitis findings; e.g purulent or mucopurulent nasal discharge

• Radiological finding of nasal tumors or fungal sinusitis.

• Any accompanying disease such as glaucoma or prostate hypertrophy or myasthenia that might be aggravated by anticholinergic therapy .

• use of systemic or local corticosteroid less than 1 month prior the study.

• Pregnancy or lactation.

• History of allergy to botox or local anesthetic agents.