Bovine Colostrum for Prophylaxis Against Recurrent Urinary Tract Infection in Children

• Status: Recruiting
• Trial end date: 2024-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Prebiotics as bovine colostrum are considered as a valuable supplement in the prevention of upper respiratory tract infections, gastrointestinal tract infections and neonatal sepsis. It contains many bioactive substances, such as immunoglobulins, lactoferrin, lysozyme, lactoperoxidase, and other growth factors.There is a lack of research on the use of prebiotics for prophylaxis against recurrent urinary tract infection (UTI) in children.In this era of increasing bacterial resistance to antimicrobial therapy, bovine colostrum can offer an approach for prophylaxis against UTI in these patients.We aim at this trial to evaluate the efficacy and safety of bovine colostrum as a prebiotic for prophylaxis against recurrent urinary tract infection in children.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University

Criteria

Inclusion Criteria:

• Documented recurrent UTI proven by positive urine culture. Recurrent UTI will be defined according to NICE guidelines as any of the following:

1. 2 or more episodes of UTI with acute pyelonephritis.

2. 1 episode of UTI with acute pyelonephritis plus 1 or more episode of UTI with cystitis.

3. 3 or more episodes of UTI with cystitis.

Exclusion Criteria:

1. Allergy or hypersensitivity to the prescribed prebiotic.

2. Presence of any endo-urinary device (ureteral stent).

3. Presence of urinary stones