Bowel Preparation in Elective Pediatric Intestinal Surgery

• Status: Unknown status
• Trial end date: 2020-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Infections after elective intestinal surgery remain a significant burden for patients and for the health care system. The cost of treating a single surgical site infection is estimated at approximately $27,000. In adult patients, there is good evidence that the combination of oral antibiotics and mechanical bowel preparation is effective at reducing infections after intestinal surgery. In children, the body of evidence is much weaker. In this population, little evidence exists for oral antibiotics reducing infections and no data exists as to the effect of combining antibiotics with mechanical bowel preparation (such as polyethylene glycol (PEG)). The goal of the proposed study is to examine the effects of oral antibiotics with and without the combined use of mechanical bowel preparation on the rate of post-operative infectious complications in children aged 6 months to 18 years. This will be compared to current practices, which is to abstain from any type of mechanical bowel preparations or oral antibiotic administration before intestinal surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: McMaster University
• Treatments: Anesthetics; Anti-Bacterial Agents; Antibiotics, Antitubercular; Cefazolin; Citric Acid; Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin stearate; Kanamycin; Magnesium Oxide; Metronidazole; Picosulfate sodium; Sodium Citrate

Criteria

Inclusion Criteria:

• Patients aged six months to eighteen years presenting to the Pediatric General Surgery service at McMaster Children's Hospital for elective colorectal surgery will be screened for inclusion in this study.

Exclusion Criteria:

• Mechanical bowel obstruction

• Known hypersensitivity to laxatives or oral antibiotics

• Congestive heart failure

• Renal insufficiency

• Other medical conditions precluding the use of either oral antibiotics or mechanical bowel preparations