Brain Mechanisms Underlying the Effect of the Motilin Receptor Agonist Erythromycin on Hunger in Normal Weight Subjects

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to investigate the role of erythromycin, a prokinetic agent, on hunger, and the brain mechanism lying behind it.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universitaire Ziekenhuizen Leuven
• Collaborators: Katholieke Universiteit Leuven; KU Leuven
• Treatments: Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin stearate

Criteria

Inclusion Criteria:

• Female only.

• Age > 18 and < 60.

• Body Mass Index (BMI) of 19-25 kg/m2 (no weight change of more than 5 kg in the past three months).

• Not known to have any chronic medical illness or illnesses affecting the gastrointestinal, cardiovascular, or nervous systems, chronic pain or psychiatric disorder.

• If female not known to be pregnant.

• Not known to have any past upper gastrointestinal surgery.

Exclusion Criteria:

• Alcohol consumption > 7 drinks / week

• Major depression and chronic health conditions except controlled hypertension