Brain Natriuretic Peptide Effects on Appetite Regulating Hormones and Endothelial Derived Peptides
Status:
Completed
Trial end date:
2011-05-01
Target enrollment:
Participant gender:
Summary
Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic
peptide (BNP) from the ventricular myocytes. The pathophysiological mechanisms linking heart
failure and appetite-regulation remain unknown. This study aims to examine the impact of
exogenous BNP administration on subjective ratings of hunger and satiety, and on
appetite-regulating hormones in a placebo-controlled cross-over study performed in ten
healthy human volunteers.