Brown Adipose Tissue Activity in Pre- and Postmenopausal Women
Status:
Recruiting
Trial end date:
2022-08-31
Target enrollment:
Participant gender:
Summary
The physiological relevance of brown adipose tissue (BAT) in humans is largely unknown. The
investigators have shown that suppressing ovarian function in premenopausal women reduces
resting energy expenditure (REE), and this is prevented by adding back estradiol (E2). The
investigators preliminary data suggest that this may be due, in part, to reduced brown
adipose tissue (BAT) activity. The overarching hypothesis is that BAT activity in humans is
modulated by E2. To determine if natural declines in endogenous E2 contribute to changes in
BAT activity, we will compare BAT activity in pre-and post-menopausal women. The
investigators will also explore whether suppression of ovarian hormones in pre-menopausal
women impairs BAT activity. BAT activity will be quantified using dynamic positron emission
topography/computed tomography (PET/CT) imaging combined with 11C-acetate tracers. We will
assess the thermogenic response of BAT by measuring cold-induced changes in REE, shivering,
and skin and core temperature.
Phase:
N/A
Details
Lead Sponsor:
University of Colorado, Denver
Collaborators:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Université de Sherbrooke University of Ottawa