Buffered Lidocaine for Loop Electrosurgical Excision Procedures (LEEPs)

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

Women undergoing a LEEP procedure who receive lidocaine buffered with sodium bicarbonate for their cervical block will experience less injection pain than women who receive plain lidocaine.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Treatments: Epinephrine; Epinephryl borate; Lidocaine; Racepinephrine

Criteria

Inclusion Criteria:

• antecedent biopsy read as

• cervical intraepithelial neoplasia (CIN) grade 2 or 3 or microinvasive cancer

• adenocarcinoma in situ

• persistent CIN 1

• antecedent pap read as

• high grade squamous intraepithelial lesion

• atypical glandular cells

• persistent low grade squamous intraepithelial lesion

Exclusion Criteria:

• anatomy unsuitable for safe office loop excision based on operator judgement

• inability to tolerate procedure under local anesthesia

• pregnancy

• age less than 18 years

• inability to understand spoken or written English

• refusal of consent

• prisoner

• mental incapacity

• anticoagulant or antiplatelet therapy, or known bleeding diathesis

• use of analgesics other than over the counter medications(OTC meds include NSAIDS or Tylenol) within 7 days of scheduled LEEP