Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection

• Status: Completed
• Trial end date: 2014-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Despite a robust multimodal pain management regimen, patients undergoing total knee arthroplasty (TKA) continue to report low satisfaction with postoperative pain management. Patient satisfaction further declines with any adverse event such as a drug reaction to neuroleptic medications or a patient fall due to a femoral nerve block. A new method of pain management throughout the hospital experience is warranted to improve patient satisfaction and the possibility of related adverse events. The purpose of this study is to examine if there is a difference in post operative pain and morphine (MSO4) total consumption for hospitalized TKA patients without femoral nerve block receiving an intra-operative periarticular injection of bupivacaine liposome suspension versus a concentrated multi drug.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: TriHealth Inc.
• Collaborator: Chris Scheuerman
• Treatments: Bupivacaine; Epinephrine; Epinephryl borate; Morphine; Racepinephrine

Criteria

Inclusion Criteria:

• TKA candidacy

• Osteoarthritis

• Failure of non-operative treatments to control knee pain

• Patients able to understand and agree to study inclusion

Exclusion Criteria:

• Subjects have orthopaedic and medical co-morbidities that would thwart postoperative pain control such as extra-articular pathology with referred pain to the knee (spinal stenosis, neuropathy,ipsilateral hip disease)

• Severe knee deformity

• Post-traumatic and inflammatory arthritis

• BMI above 40

• Patients unable to receive multimodal pain remitting agents

• Active knee sepsis

• Remote sites of active infection

• Diabetes with A1C > 7

• ASA class > lll

• Cardiac disease failing medical clearance

• Severe liver disease

• PAD with AAI < 0.75

• Seizure disorder

• Allergic to any pain remitting agent

• Alcohol abuse

• Smoking abuse